男性不妊における主要組織適合抗原(HLA)および免疫globulinにかんする研究

Abstract

For the purpose of immunological investigation of male infertility, lymphocytes of 50 patients with germ cell aplasia diagnosed by testicular biopsy and 50 normal controls were examined for HLA antigen by microcytotoxicity test. The level of serum and seminal-plasma immunoglobulin of 216 patients with oligospermia, 91 with azoospermia and 50 normal controls were studied using the single radial immunodiffusion method. I) HLA-BW35 was found in 38% of 50 patients with germ cell aplasia and 8% of 50 normal controls. HLA-BW35 was associated with male infertility at a significant level (p<0.005). 2) In infertility patients, it was revealed that serum immunoglobulin level was mueh more increased than that in normal controls, and the level of patients with azoospermia was the highest among the patients. 3) In infertility patients, seminal-plasma immunoglobulin level was much more increased than that in normal controls, and the mean value in patients with azoospermia was the highest among the patients. 4) In patients who were found to have HLA-BW35, seminal-plasma immunoglobulin level was much more increased than that in patients not having HLA-BW35.