1. Kyoto University Research Information Repository
  2. 060　医学研究科・医学部・医学部附属病院
  3. 泌尿器科紀要
  4. Vol.24 No.1
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    このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/2433/122166
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dc.contributor.author竹内, 秀雄ja
dc.contributor.author大石, 賢二ja
dc.contributor.author吉田, 修ja
dc.contributor.author小橋, 恭一ja
dc.contributor.author竹部, 幸子ja
dc.contributor.author長谷, 純一ja
dc.contributor.alternativeTakeuchi, Hideoen
dc.contributor.alternativeOishi, Kenjien
dc.contributor.alternativeYoshida, Osamuen
dc.contributor.alternativeKobashi, Kyoichien
dc.contributor.alternativeTakebe, Sachikoen
dc.contributor.alternativeHase, Jun'ichien
dc.date.accessioned2010-07-06T11:18:54Z-
dc.date.available2010-07-06T11:18:54Z-
dc.date.issued1978-01-
dc.identifier.issn0018-1994-
dc.identifier.urihttp://hdl.handle.net/2433/122166-
dc.description.abstractHydroxamic acid, a potent and specific inhibitor of bacterial urease activity, was found to be effective for the prevention of alkalinization of infected urine and bladder stone formation. 1. Among new hydroxamic acid derivatives of hippuric acid, m-methoxyhippurohydroxamic acid (UCD II) was expected to be most effective, because of the strong inhibitory power against urease activity and the high urinary excretion in rats without degradation. 2. UCD II prevented the alkalinization of experimentally infected urine in vitro. 3. UCD II significantly prevented the bladder stone formation as well as alkalinization of urine in vivo, when the compound was orally administered to the rats with urinary tract infection caused by Proteus mirabilis. 4. Clinical application of UCD II was dependent upon the evaluation of safety of the compound, with reference to the prevention of pathologic sequelae of urinary infection with urease-producing bacteria.en
dc.format.mimetypeapplication/pdf-
dc.language.isojpn-
dc.publisher京都大学医学部泌尿器科学教室ja
dc.publisher.alternativeDepartment of Urology, Faculty of Medicine, Kyoto Univeersityen
dc.subject.ndc494.9-
dc.titleウレアーゼ阻害剤による尿路結石の予防 第3報 : 新ヒドロキサム酸誘導体によるウレアーゼ阻害と膀胱結石形成の防止ja
dc.title.alternativePREVENTION OF INFECTED URINARY STONES BY UREASE INHIBITORen
dc.typedepartmental bulletin paper-
dc.type.niitypeDepartmental Bulletin Paper-
dc.identifier.ncidAN00208315-
dc.identifier.jtitle泌尿器科紀要ja
dc.identifier.volume24-
dc.identifier.issue1-
dc.identifier.spage21-
dc.identifier.epage26-
dc.textversionpublisher-
dc.sortkey03-
dc.address京都大学医学部泌尿器科学教室ja
dc.address富山大学薬学部薬品生物化学教室ja
dc.address.alternativeThe Department of Urology, Faculty of Medicine, Kyoto Universityen
dc.address.alternativeThe Faculty of Pharmaceutical Sciences, University of Toyamaen
dcterms.accessRightsopen access-
dc.identifier.pissn0018-1994-
dc.identifier.jtitle-alternativeActa urologica Japonicala
dc.identifier.jtitle-alternativeHinyokika Kiyoen
出現コレクション:Vol.24 No.1

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