前立腺肥大症に対するPhenoxybenzamineの使用経験

Abstract

Seventeen patients with benign prostatic hypertrophy have been treated by an oral administration of phenoxybenzamine (POB) 5 mg daily for 14 days. The effectiveness was determined by scoring the relief degree of symptoms or complaints related to micturition, and by physical findings such as the amount of residual urine, uroflowmetric and cystometric patterns, and urethral pressure profile. The results obtained are as follows: 1. Relief of the symptoms or complaints was obtained in 12 patients (70.6%), and the decrease of nocturnal frequency in 13 patients (76.5%) (p<0.01). 2. The decrease of residual urine was obtained in 12 patients (70.6%). 3. The estimation of posterior urethral pressure was undertaken in 4 patients and there was no significant decrease after the administration. 4. Neither subjective nor objective side effects were observed in the patients. From the results, POB was considered a useful drug in the conservative treatment of benign prostatic hypertrophy.