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Title: 膀胱腫瘍に対するMMCおよびCytosine Arabinosideの膀胱内注入療法
Authors: 加藤, 廣海  KAKEN_name
多田, 茂  KAKEN_name
斎藤, 薫  KAKEN_name
山崎, 義久  KAKEN_name
朴木, 繁博  KAKEN_name
波部, 英夫  KAKEN_name
鈴木, 紀元  KAKEN_name
浜野, 耕一郎  KAKEN_name
堀内, 英輔  KAKEN_name
森下, 文夫  KAKEN_name
栃木, 宏水  KAKEN_name
浦田, 英男  KAKEN_name
米田, 勝紀  KAKEN_name
前田, 真  KAKEN_name
田島, 和洋  KAKEN_name
Author's alias: Kato, Hiromi
Tada, Shigeru
Saito, Kaoru
Yamazaki, Yoshihisa
Honoki, Shigehiro
Habe, Hideo
Suzuki, Norimoto
Hamano, Koichiro
Horiuchi, Eisuke
Morishita, Fumio
Tochigi, Hiromi
Urata, Hideo
Kometa, Katsunori
Maeda, Makoto
Tajima, Kazuhiro
Issue Date: Jul-1978
Publisher: 京都大学医学部泌尿器科学教室
Journal title: 泌尿器科紀要
Volume: 24
Issue: 7
Start page: 595
End page: 608
Abstract: Intravesical combination chemotherapy was performed in 48 cases with bladder tumors. Mitomycin C 10 mg was administered concomitantly with cytosine arabinoside 20 mg (4 cases, group A), 100 mg (21 cases, group B), 200 mg (3 cases, group C) or 300 mg (20 cases, group D). The clinical results were as follows: 1) Complete disappearance of tumors was found in 24% of group B, in 33% of group C, and in 35% of group D. Clinical improvement including complete disappearance of tumors was found in 25% of group A, in 57% of group B, in 67% of group C, and in 80% of group D. 2) Side effects were found in 25% of group A, in 9.5% of group B, in 33% of group C, and in 20% of group D. But most of them were minor side effects. 3) Recurrence rate was 2.7% within 6 months, and 5% within 18 months. 4) It was concluded that the treatment with mitomycin C 10 mg and cytosine arabinoside 100 mg was satisfactory in the tumors (pedunculated, papillary, of smaller size than the small finger head, or of grade I). The necessary dosage of mitomycin C was 10 mg and that of cytosine arabinoside was 300 mg for the tumor of larger size than the thumb tip even pedunculated, the sessile tumor or the tumor of above gradeII.
Appears in Collections:Vol.24 No.7

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