膀胱腫瘍に対するMMCおよびCytosine Arabinosideの膀胱内注入療法

Abstract

Intravesical combination chemotherapy was performed in 48 cases with bladder tumors. Mitomycin C 10 mg was administered concomitantly with cytosine arabinoside 20 mg (4 cases, group A), 100 mg (21 cases, group B), 200 mg (3 cases, group C) or 300 mg (20 cases, group D). The clinical results were as follows: 1) Complete disappearance of tumors was found in 24% of group B, in 33% of group C, and in 35% of group D. Clinical improvement including complete disappearance of tumors was found in 25% of group A, in 57% of group B, in 67% of group C, and in 80% of group D. 2) Side effects were found in 25% of group A, in 9.5% of group B, in 33% of group C, and in 20% of group D. But most of them were minor side effects. 3) Recurrence rate was 2.7% within 6 months, and 5% within 18 months. 4) It was concluded that the treatment with mitomycin C 10 mg and cytosine arabinoside 100 mg was satisfactory in the tumors (pedunculated, papillary, of smaller size than the small finger head, or of grade I). The necessary dosage of mitomycin C was 10 mg and that of cytosine arabinoside was 300 mg for the tumor of larger size than the thumb tip even pedunculated, the sessile tumor or the tumor of above gradeII.