当教室における進行膀胱癌の化学療法

Abstract

Twenty-eight cases with advanced bladder cancer treated by chemotherapy in our department were analysed, and the following results were obtained. 1) Twenty-one cases were male and 7 were female. Range of age was from 31 years old to 84 (average: 58.8 y.o.). Twenty-two cases were transitional cell carcinoma (grade 2:3 cases, grade 3: 14, grade 4: 5). Five cases were squamous cell carcinoma and I was adenocarcinoma. Clinical stage of all cases exceeded T3 in TNM classification. 2) Systemic administration (intravenous infusion) was carried out on 21 cases, intravesical instiliation on 13, local injection on 1 and oral administration on 6, respectively. Used drugs were cyclophosphamide, chromomycin-A3, mitomycin C, cytarabine, bleomycin and carboquone. These were given in single or combined agents. 3) Nineteen cases (68%) died of cancer. Three cases survived above 5 years and I of them became healthy without urological malignancy. Side-effects were generally mild and well tolerated. Although good results were limited to a few cases in our department, we believe that aggressive therapy and new anticancer agents will salvage more cases of advanced bladder cancer.