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Title: ヒト腎細胞癌の基礎的研究 第3報: 腎細胞癌組織内にみられた新しいγ-glutamyl transpeptidaseアイソザイムについて
Other Titles: FUNDAMENTAL STUDY OF RENAL CELL CARCINOMA PART3. A NOVEL γ-GTP ISOZYME DETECTED IN RENAL CELL CARCINOMA TISSUE
Authors: 波田, 寿一  KAKEN_name
東野,一彌  KAKEN_name
山本, 英雄  KAKEN_name
渡辺, 信一郎  KAKEN_name
松田, 稔  KAKEN_name
長船, 匡男  KAKEN_name
宇佐美, 道之  KAKEN_name
古武, 敏彦  KAKEN_name
園田, 孝夫  KAKEN_name
Author's alias: Hada, Toshikazu
Higashino, Kazuya
Yamamoto, Hideo
Watanabe, Shinichiro
Matsuda, Minoru
Osafune, Masao
Usami, Michiyuki
Kotake, Toshihiko
Sonoda, Takao
Issue Date: Aug-1978
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 24
Issue: 8
Start page: 631
End page: 637
Abstract: Gamma-glutamyl transpeptidase (γ-GTP, E.C. 2.3.2.1) has been considered to be a member of γ-glutamyl cycle and playa physiological role in the transport of amino acids across cell membrane through this cycle. This enzyme was extracted from cancerous tissue obtained from 10 patients with renal cell carcinoma. These enzyme preparations were investigated electrophoretic ally and enzymologically in comparison with the enzyme of normal renal tissue, normal liver tissue and fetal renal tissue. The results obtained were as follows. 1) Five cancerous tissues had a novel γ-GTP which was electrophoretic ally different from that of normal kidney, fetal kidney or normal liver. Other properties of the novel γ-GTP were almost the same as that of normal kidney except molecular weight. 2) Molecular weight of the novel γ-GTP was about 130,000, while that of normal kidney was approximately 90,000.  3) With regard to the possible relationship between the histopathological findings of the renal cell carcinoma and the presence of the novel γ-GTP, it was revealed that the novel enzyme was detected more frequently in poorly differentiated renal cell carcinoma or in the tumor composed mainly of granular cells. Further investigation is necessary to establish the clinical significance of the novel γ-GTP, but at least it is suggested that this enzyme might be a biochemical marker of poorly differentiated renal cell carcinoma.
URI: http://hdl.handle.net/2433/122251
Appears in Collections:Vol.24 No.8

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