尿管結石の自然排出について とくに臭化チメピジウムの影響についての検討

Abstract

The effects of an antispasmodic agent, timepidium bromide (SESDEN®), on spontaneous passage of ureteral calculi were studied. First, various conditions of calculi in terms of spontaneous passage were discussed. The size of calculi is regarded as the most important factor in such stone passage. We used a report of Minami et al. for grouping the size of calculi and for further facilitation of this grouping ellipsoids were cubed on the basis of the values obtained from their radiograph. As a result, the upper limit of small calculi was 65.5 mm3 and that of medium ones, 188.5 mm3. On the other hand, it was confirmed, judging from the appearance of the outer margin of calculi on radiograph, that smooth ones passed earlier than jagged ones. The effects of some antispasmodics upon the passage of calculi, which were reported by other authors, were compared with those of timepidium bromide. It was found that the effects of this drug on the calculi passage throughout the whole period of administration were comparable with those described elsewhere on other drugs. In the course of administration of this drug, it was noted that owing to its analgesic properties, there were only few cases in which pain developed so that more potent analgesic agent was needed for treatment. In spite of the long-term administration of this drug, no noticeable side effects were observed.