いわゆるUnstable Bladderに対するFlavoxate Hydrochlorideの効果について - とくにUrodynamic Examinationからの評価 -

Abstract

Flavoxate hydrochloride was given to 20 patients consisting of 9 children and 11 grown-ups. 11 patients were diagnosed as uninhibited neurogenic bladder, 4 patients as bladder neurosis and 5 patients as unstable bladder syndrome. 67% of patients showed improvements of subjective symptoms in overall assessment. As to objective observations, there was 50 to 75% increase in bladder volume both at the minimum and maximum desire to void, but intravesical pressure at maximum urination remained almost unchanged. There was no effect on maximum voiding pressure except a little decrease in it in the group of uninhibited neurogenic bladder. It was guessed that a combined therapy with the present drug and anticholinergic agents would be one of the effective means for the treatment of uninhibited neurogenic bladder.