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タイトル: | 前立腺肥大症に対する塩酸タムスロシン0.2 mg から0.3 mg への増量効果の検討 |
その他のタイトル: | Clinical Effects of Increase in the Loading Dose of Tamsulosin (from 0.2 mg to 0.3 mg) on Urinary Disturbance Associated with Benign Prostate Hyperplasia |
著者: | 久松, 浩 山下, 修史 |
著者名の別形: | Hisamatsu, Hiroshi Yamashita, Syuji |
キーワード: | Tamusulosin Loading dose Benign prostate hyperplasia |
発行日: | Jun-2010 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 56 |
号: | 6 |
開始ページ: | 297 |
終了ページ: | 300 |
抄録: | We determined the clinical efficacy of a loading dose of tamsulosin (0.2-0.3 mg) in patients with benign prostate hyperplasia (BPH). Tamsulosin was administered at a dose of 0.3 mg to 26 patients with BPH and moderate or severe urinary disturbance, as determined on the basis of the international prostate symptom score (I-PSS) and quality of life (QOL) severity. The I-PSS and QOL index were caluculated before and at the end of the 12-week administration period. The total I-PSS and QOL index were significantly decreased at 12 weeks compared with the baseline (p=0.003, and p=0.011, respectively). Significant differences were observed in the changes in 3 I-PSS items (stream, p=0.042 ; nocturia, p=0.012 ; urgency, p=0.003). On the basis of these findings, we conclude that the administration of 0.3 mg tamsulosin to patients with BPH improves the scores of objective indexes, and may specifically ameliorate urinary storage symptoms. |
著作権等: | 許諾条件により本文は2011-07-01に公開 |
URI: | http://hdl.handle.net/2433/122353 |
PubMed ID: | 20610919 |
出現コレクション: | Vol.56 No.6 |
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