排尿障害患者に対するPhenoxybenzamineの使用経験

Abstract

Phenoxybenzamine was administered to the patients who visited our clinics complaining of difficulty in urination. Total of 107 patients, 99 male patients and 8 female patients, were treated with phenoxybenzamineand symptomatic improvement was observed in 83 (77.6%). Diagnosis included were bladder neck contracture (58 cases), benign prostatic hyperplasia (24 cases) and others including neurogenic bladder dysfunction and chronic prostatitis etc. (25 cases). Effective rate was higher in elderly patients. No difference in effective rate was noticed between 5 mg/day group and 10 mg/day group. Urodynamic studies were done in some of the cases. Uroflowmetry was done in 13 cases, including 11 good and 2 poor cases. Improvement in flowmetric data was noticed in all good cases and no improvement in poor cases. In urethral pressure profiling, decrease in UPmax was also noticed in good cases. Surgery was indicated in the patients of benign prostatic hyperplasia who had had frequent recurrence of urinary retention previous to medication and in bladder neck contracture who did notrespond to phenoxybenzamine. Transurethral resection was done in 12 of 24 cases of benign prostatic hyperplasia andin 5 of 58 of bladder neck contracture. Histological diagnosis of the latter was fibromuscular hyperplasia in all cases. Nasal stiffness, light headedness, palpitation, thirst, vesical irritation symptoms, lethargy and malaise were the untoward reactions noticed and in 12 patients medication was discontinued because of these reactions. Phenoxybenzamine call be. administered to the patients suffering from urinary obstruction for symptomatic relief and for deciding precise indication of surgery.