cis-Diamminedichloride Platinum(CDDP)による非セミノーム睾丸腫瘍の化学療法 : 症例とヌードマウスを用いた抗癌剤感受性試験について

Abstract

A l7-year-old man with disseminated nonseminomatous testicular tumor had been treated with combination chemotherapy regimen of actinomycin D, vincristine, bleomycin and methotrexate and cobalt-60 irradiation to the lung and the para-aortic lymph nodes. The patient responded well to the therapy, however in 12 months metastatic lesions in the lung and the para-aortic lymph nodes developed again. Then the patient was placed on chemotherapy with the regimen of CDDP, vinblastine and bleomycin. The patient markedly improved both subjectively and objectively. The original testicular tumor was transplanted in the nude mice and CDDP and the regimen of vincristine, actinomycin D, bleomycin were tested for sensitivities. The results obtained from the experiment closely corresponded with the clinical course. The purpose of this report is to present the case and discuss the CDDP regimen and sensitivity test of anticancer drugs using the transplanted testicular tumor in the nude mice.