複雑性尿路感染症に対するリラシリン(SBPC)大量療法の検討 -Aminoglycoside系薬剤とVenoglobulinとの併用について-

Abstract

Of 10 cases with complicated chronic pyelonephritis admitted to our hospital, sulfobenzylpenicillin (SBPC) was administrated 20 gm in a day for six to twelve days intravenously, and combined treatments with aminoglycosides and/or venoglobulin were performed in seven cases. Underlying diseases were renal calculi in two cases, hydronephrosis in one case, prostatic hyperplasia in three cases, bladder cancer in two cases and uterine cancer in two cases. Following results were obtained. 1) Clinical results were excellent in three cases, good in six cases and poor in one case. 2) Isolated organisms in eight cases had no sensitivity to SBPC but clinical effectiveness was good in seven cases. Large dose administration of SBPC gave a good result despite of insensitive drugs. 3) Glucose non-fermentative gram negative bacilli were isolated from four cases and clinical effectiveness was obtained in three cases of them. 4) No serious side effects were observed throughout this series.