原発性副甲状腺機能亢進症術後の低カルシウム血症 --その統計的観察とIα-OH-D3投与後の検討--

Abstract

Postoperative hypocalcemia in primary hyperparathyroidism, an unavoidable complication, was studied statistically. Two types were recognized in the pattern of the postoperative hypocalcemia. One was that the recovery of serum calcium level was observed in the early period, 5th to 7th day postoperatively and the other was the prolonged severe hypocalcemia lasting more than 2 weeks postoperatively. Then, 1α-OH•D3, which is expected to be converted to active form of vitamin D3, 1, 25- (OH)2-D3, by 25-hydroxylation in the liver, was used for the treatment of the six hypocalcemic patients belonging to the latter type. In the results, lα-OH-D3 was safe and effective so far as being controlled by serum calcium and urinary calcium excretion. We emphasize that the excessive excision of the parathyroid glands should be avoided because the long-term management of the postoperative hypocalcemia is troublesome even by lα-OH-D3.