前立腺癌に対する放射線併用療法

Abstract

Between 1973 and Oct. 1978, 50 patients with prostatic carcinoma were treated with anti-androgen therapy and, of these 11 cases also received radiotherapy. Post-treatment needle biopsies of the prostate were done about 6 weeks later. Histologically, in the radiation therapy group increased fibrotic reaction and decrease of gland or gland-like structure were marked. These reactions were degenerative change and so, radiotherapy of the prostatic carcinoma was effective. Additionally, marked fibrosis caused by radiation will disturb entrance of anti-androgen drug to the prostatic carcinoma, so that following anti-androgen therapy may be un-effective.