夜間頻尿に対するBumetanideの効果

Abstract

The management of nocturia is the problem, so we studied the effect of a diuretic, bumetanide, on the 23 patients with nocturia due to benign prostatic hyperplasia, prostatic cancer, prostatitis and so on. Bumetanide has a rapid action on electrolyte excretion similar to that of furosemide which lasts only 4 or 5 hours. Being given an I mg tablet of bumetanide at 1:00 pm., the improvement of the symptom was observed in 17 patients(73.8%). No electrolyte complications and other side effects were not seen. In the same manner, we investigated the effect of a single oral dose of bumetanide on the 8 normal volunteers and 3 patients with benign prostatic hyperplasia. The diuresis occurred right after the administration of bumetanide, and the urine volume was less at night than that in the daytime. It is thought that the improvement of nocturia is partly due to the diuresis caused by bumetanide.