尿路結石と尿酸代謝異常

Abstract

Metabolic studies in 136 patients with calcium renal stone, with special regard to the serum and urine uric acids, have shown the following findings. 1. The serum uric acid level was higher and the uric acid clearance was lower in the male patients than in the female (figure 2). No significant deviation of the serum and urine uric acids was found from the viewpoint of age, as shown in table 1. 2. The level of serum and urinary uric acids were slightly higher in calcium stone formers than in non-stone formers, but not being statistically significant. 3. Between urinary calcium and uric acid excretions a positive but feeble correlation was observed (figure 1). Between uric acid clearance and tubular reabsorption of calcium a negative correlation was found (figure 3). The level of calcium and uric acid excretions with 24-hour-urine tended to be somewhat higher in the male patients as shown in figure 1. The result is considered to have some causal relation to the fact that oxalate urolith is frequently found in the male. 4. In the patients with hyperuricemia the stone was likely to recur. Hyperuricosuria, on the other hand, did not appear to accelerate the recurrence. But, this should be reexamined by a more exact procedure. These results suggest the existence of some correlation between the metabolisms of uric acid and of calcium. The authors here emphasize that it is necessary to observe the calcium stone formers carefully as regard to the uric acid metabolim and to correct the disorder, if it is found, for the prevention of new stone formation.