副甲状腺手術後の低カルシウム血症に対する合成活性型ビタミンDの使用経験

Abstract

A synthetic analogue of active form of Vita mine D (1α-OH D3) was administered to three patients with hypocalcemia following parathyroidectomy for primary hyperparathyroidism and its effect on hypocalcemic and hyperphosphatemic states was discussed. Owing to recent advance of Vitamine D metabolism, it was elucidated that postoperative hypoparathyroidism is pathophysiologic ally one of Vitamine D deficient states. 1α-OH D3 replaced the Vitamine D substances (cholecalciferol or ergocalciferol) and produced increased levels of calcium and decreased levels of phosphate in the blood. However, its cessation led to a rapid decrease of calciurn levels in the blood to avoid calcium intoxication.