Cushing症候群に見られた多発性副腎腺腫の1例

Abstract

A 48-year-old woman still had general fatigue, hypertension, diabetes mellitus, and a Cushinglike appearance, after discontinuing steroid treatment for bronchial asthma. Laboratory values included urinary 17-hydroxycorticoid levels of 41.9 mg/day, which remained unchanged with ACTH stimulation and could not be suppressed with 8 mg of dexamethazone and nor elevated with metopirone. Adrenal scintigraphy by [131]I-adosterol showed right adrenal adenoma. Right adrenalectomy was conducted, and two adrenal tumors were observed macroscopically. They were diagnosed adrenocortical adenoma histopathologically, and the larger one was studied electronmicroscopically. This patient has remained well for one year with no evidence of Cushing syndrome and with normal hydrocorticoid values. A similar case was found in the Japanese literature.