キロサイド膀胱内注入による膀胱腫瘍の再発防止効果

Abstract

Intravesical instillation of Cylocide was carried out in 113 cases with urinary bladder tumors for the purpose of prophylaxis of the recurrence of bladder tumors after removal. Aqueous or saline solution containing Cylocide 200 mg was usually instilled into the bladder once every week for 15 weeks after operation and the results were followed up for from one to 4 years. The actuarial recurrence rate of the 113 cases treated with Cylocide was 25.1 % within one year, 38.7% within 2 years, 54.3% within 3 and 4 years. No severe side effects were observed during the instillation period, while bladder irritability was complained in 3 of 108 cases (2.8%) and leukopenia was noticed in 5 of 102 cases (4.9%). On the results of our studies, it is concluded that the prophylactic instillation therapy with Cylocide is useful for the prevention of recurrence of bladder tumors after removal.