HETEROTRANSPLANTATION OF TRANSPLANTABLE HUMAN UROGENITAL MALIGNANT NEOPLASMS TO THYMECTOMIZED ANTITHYMOCYTE SERUM TREATED NEONATAL HAMSTERS

Abstract

ヌードマウス可移植性ヒ卜泌尿生殖器腫瘍のうち， われわれが保持している未分佑型前立腺癌，膀胱移行上皮癌，腎細胞癌について胸腺摘出後, ATSを投与した新生児ハムスターにそれぞれ皮下移植をこころみた。これらの腫腫は， ヌードマウスにおける継代移植時におけるときと, (1) やや発育が遅く， (2) 周囲組織との癒着性，が存在しているのが相違点であった。ただし移植時に比して，あきらかに腫瘍の増大が認められ，通常飼育下で実験動物としての使用される可能性があるものと考えられた。

Experiments representing an attempt to transplant human urogenital malignant tumors transplantable in nude mice to anti thymocyte serum (ATS)-treated, thymectomized neonatal hamsters were conducted, with the results assessed in comparison with those in nude mice, using specimens from human anaplastic prostatic adenocarcinoma, transitional cell carcinoma of the bladder and renal cell carcinoma. These tumors transplanted grew somewhat slower in hamsters and showed a slightly pronounced tendency of adherence to surrounding tissues, compared to those in nude mice. There was no evidence of metastasis of the tumors transplanted in hamsters and nude mice. The results of the experiments suggest possibilities of development of laboratory animals in which human malignant tumors of the urogenital system may be transplanted under ordinary conditions of feeding.