オキソニン酸による実験的高尿酸血症 - 特に尿酸沈着と尿pHについて -

Abstract

The biochemical and morphologic studies were performed in hyperuricemic rats produced by feeding 1 % uric acid and 5% oxonic acid. After 7 days of feeding, rats had deposits of uric acid and urate crystals within the collecting tubules of the renal papillae. Addition of 2% sodium bicarbonate or 2% ammonium chloride to the hyperuricemic diet did not affect the crystal deposition in the kidney, while addition of sodium bicarbonate reduced the precipitation of uric acid in the bladder. The oxonic acid-treated rat may serve as a useful animal model for the study of hyperuricemia and uric acid urolithiasis.