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Title: 膀胱腫瘍に対するCarboquone膀胱腔内注入療法の基礎的,臨床的検討
Other Titles: FUNDAMENTAL AND CLINICAL STUDIES ON INTRA-VERICAL INFUSION OF CARBOQUONE FOR TREATMENT OF BLADDER TUMOR
Authors: 小野, 浩  KAKEN_name
広本, 宣彦  KAKEN_name
中津, 博  KAKEN_name
碓井, 亜  KAKEN_name
藤井, 元広  KAKEN_name
相模, 浩二  KAKEN_name
畑地, 康助  KAKEN_name
鵜飼, 麟三  KAKEN_name
仁平, 寛巳  KAKEN_name
福重, 満  KAKEN_name
平山, 多秋  KAKEN_name
松木, 暁  KAKEN_name
梶尾, 克彦  KAKEN_name
白石, 恒雄  KAKEN_name
林, 睦雄  KAKEN_name
Author's alias: Ono, Hiroshi
Hiromoto, Nobuhiko
Nakatsu, Hiroshi
Usui, Tsuguru
Fujii, Motohiro
Sagami, Kouji
Hatachi, Kousuke
Ukai, Rinzo
Nihira, Hiromi
Fukushige, Mitsuru
Hirayama, Masaaki
Matsuki, Satoru
Kajio, Katsuhiko
Shiraishi, Tsuneo
Hayashi, Mutsuo
Issue Date: May-1980
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 26
Issue: 5
Start page: 619
End page: 627
Abstract: Carboquone preparations, Esquinone for injection and Esquinone injection, were infused into the bladder to investigate their antitumor activity and inactivation of carboquone in urine in 72 patients with superficial bladder tumors. The following conclusions were obtained: 1. Stability of carboquone was highly dependent on pH of the urine mixed with it. Its inactivation was marked at acidic pH. Reduction of the amount of urine during infusion and use of a larger amount of diluent are important to prevent the inactivation of carboquone. 2. Intra-vesical infusion of carboquone was evaluated to be effective in 51.4% patients. 3. No special difference in effectiveness was found between Esquinone for injection and Esquinone injection. 4. No difference in effectiveness was found between the patients with primary tumors and those with recurrent tumors. 5. As for side effects, Esquinone for injection and Esquinone injection caused irritant symptoms of the bladder in 36.4 and 52.0% of patients, respectively. 6. Carboquinone infused into the bladder had no influence on peripheral blood, liver function, and renal function.
URI: http://hdl.handle.net/2433/122637
Appears in Collections:Vol.26 No.5

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