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dc.contributor.author川村, 寿一ja
dc.contributor.author添田, 朝樹ja
dc.contributor.author吉田, 修ja
dc.contributor.author高坂, 唯子ja
dc.contributor.author森田, 陸司ja
dc.contributor.author鳥塚, 莞爾ja
dc.contributor.alternativeKawamura, Juichija
dc.contributor.alternativeSoeda, Asakija
dc.contributor.alternativeYoshida, Osamuja
dc.contributor.alternativeKosaka, Tadakoja
dc.contributor.alternativeMorita, Rikushija
dc.contributor.alternativeTorizuka, Kanjija
dc.date.accessioned2010-07-22T06:16:28Z-
dc.date.available2010-07-22T06:16:28Z-
dc.date.issued1980-05ja
dc.identifier.issn0018-1994ja
dc.identifier.urihttp://hdl.handle.net/2433/122650-
dc.description.abstractSerum and urinaryβ2microglobulin levels were measured, by radioimmunoassay, in 29 patients with urogenital malignancies who were treated by different modes of anticancer chemotherapy. While the level of serum β2microglobulin paralleled that of serum creatinine or creatinine clearance in the healthy control, no good correlation was seen between the level of β2microglobulin and that of serum creatinine or creatinine clearance in the patients. Although abnormally high levels of serum β2microglobulin were seen in 4 patients with normal creatinine clearance, the elevation of serum β2 micro globulin paralleled the decrease in renal function in most patients. When serumβ2microglobulin or creatinine clearance on the logalithmic scale is plotted against the urinary excretion ofβ2microglobulin (24 hours excretion of β2 micro globulin, β2microglobulin clearance orβ2microglobulin clearance/creatinine clearance) on the logalithmic scale, 4 patterns of renel impairment are delineated on the graph; normal levels of serumβ2microglobulin or creatinine clearance with normal levels of β2microglobulin excretions indicate normal renal function ("Normal"), normal levels of serum β2microglobulin or creatinine clearance with the elevation of β2microglobulin excretions indicate the pattern of tubular impairment ("Tubular"), abnormal levels of increased serum β2microglobulin or decreased creatinine clearance with normal levels of β2microglobulin excretions indicate the pattern of glomerular impairment ("Glomerular") and abnormal levels of β2microglobulin or creatinine clearance with the elevation of β2microglobulin excretions indicate the pattern of both glomerular and tubular impairments ("Glomerular+Tubular"). Most of patients revealed the pattern of "Glomerular + Tubular" or that of "Glomerular". This was attributed to the loss of functioning nephrons due to primary renal diseases (e.g. solitary kidney, hydronephrosis, pyelonephritis, hypertensive nephropathies). In spite of an appearance of the pattern of "Tubular" with the course of the chemotherapy, the renal function returned to the normal ranges during the interval of cessation of the administration. However, in some patients, the pattern of "Tubular" still existed in the association with the pattern of "Glomerular". Although a transient decrease in creatinine clearance and increase in β2microglobulin excretions associated with recovery was observed repeatedly in each course of the therapy, a trend of a decrease in renal function was evident through the entire course of chemotherapy. In conclusion, determination of serum and urinary β2microglobulin is a useful adjunct for assessing changes in renal function and detecting tubular damage with anticancer chemotherapy. A correlation study between serum β2microglobulin or creatinine clearance and urinary excretions of β2microglobulin enables to classify the pattern of renal impairment.ja
dc.format.mimetypeapplication/pdfja
dc.language.isojpnja
dc.publisher泌尿器科紀要刊行会ja
dc.subject.ndc494.9ja
dc.title泌尿器科領域悪性腫瘍の化学療法中にみられる腎障害の研究 - 腎障害の早期発見のための血中ならびに尿中β2-Microglobulin測定の有用性 -ja
dc.title.alternativeEFFECTS OF ANTI-CANCER CHEMOTHERAPY ON THE RENAL FUNCTION IN THE PATIENTS WITH UROGENITAL MALIGNACIES - DETERMINATION OF βMICROGLOBULIN IN BLOOD AND URINE FOR ASSESSING RENAL IMPAIRMENT -ja
dc.type.niitypeDepartmental Bulletin Paperja
dc.identifier.ncidAN00208315ja
dc.identifier.jtitle泌尿器科紀要ja
dc.identifier.volume26ja
dc.identifier.issue5ja
dc.identifier.spage517ja
dc.identifier.epage526ja
dc.textversionpublisherja
dc.sortkey02ja
dc.address京都大学医学部泌尿器科学教室ja
dc.address京都大学医学部放射線核医学科教室ja
dc.address.alternativeThe Departments of Urology, Faculty of Medicine, Kyoto Universityandja
dc.address.alternativeThe Departments of Nuclear Medicine, Faculty of Medicine, Kyoto Universityja
Appears in Collections:Vol.26 No.5

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