抗癌剤の経膀胱的吸収に関する研究 -膀胱内注入療法の基礎- 第3報 Adriamycinの膀胱腫瘍組織内濃度

Abstract

The absorption of adriamycin through the human bladder was studied, and following results were obtained : 1. Urinary excretion of the instilled adriamycin. Studies were made concerning 4 cases in which urinary diversion was forced by progressive vesical carcinoma. After the instillation of adriamycin (60 mg/20 ml saline) over a one hour period, blood samples and the urine were collected every hour for 6 hours. The blood concentrations of adriamycin after the instillation were trace. Concerning the amount of adriamycin excreted into the urine of patients with urinary diverstion, 0.41±0.19% was excreted druing 6 hours on average. 2. Tissue concentration of adriamycin in patients with vesical cancer. Eighteen patients with vesical carcinoma were examined. Microscopic examination established a dignosis of trasitional cell carcinoma in 14 cases and anaplastic carcinoma in 4 cases. Adriamycin (60 mg/20 ml saline) was instilled in the bladder. One hour later, the tumors were collected by TUR or cystectomy. The average concentration of adriamycin in the tissues of the bladder carcinoma was 10.3 ± 14.4µg/g. The average concentration of transitional cell carcinoma was 5.3±4.5 µg/g and that of anaplastic carcinoma was 27.1±21.8µg/g.