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Title: 前立腺癌に対するEstramustine Phosphate(Estracyt)療法の臨床的,内分泌学的検討
Other Titles: THERAPEUTIC EFFECTS AND ENDOCRINOLOGICAL STUDIES ON ESTRAMUSTINE PHOSPHATE THERAPY IN PATIENTS W ITH PROSTATIC CARCINOMA
Authors: 藤井, 浩  KAKEN_name
北島, 直登  KAKEN_name
野口, 和美  KAKEN_name
穂坂, 正彦  KAKEN_name
西村, 隆一  KAKEN_name
高井, 修道  KAKEN_name
Author's alias: Fujii, Hiroshi
Kitajima, Naoto
Noguchi, Kazumi
Hosaka, Masahiko
Nishimura, Ryuichi
Takai, Shudo
Issue Date: Dec-1980
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 26
Issue: 12
Start page: 1587
End page: 1594
Abstract: Evaluation of therapeutic effects and endocrinological studies of Estramustine Phosphate (Estracyt/EMP) were made in 14 patients with prostatic carcinoma. Seven out of 14 patients without previous antiandrogenic medication showed objective response to EMP treatment. In the other patients with relapse, one showed subjective response but 6 showed no response to EMP treatment. Plasma LH, FSH, testosterone and 5a-dihydrotestosterone were measured by a specific radioimmunoassay in 10 patients with prostatic carcinoma before and during EMP treatment. The clinical statuses of the 10 patients were as follows: Four had received no treatment before EMP administration; namely fresh cases, the other 4 had been treated inadequately; namely false reactivated cases and the remainder were true reactivated cases. Plasma testosterone, 5a-dihydrotestosterone and gonadotropins concentrations decreased significantly in fresh cases and false reactivated cases. The cases of true reactivation showed no change in plasma testosterone and 5a-dihydrotestosterone levels after administration of EMP. From the results mentioned above, it was noted that no significant difference of hormonal effect was found between oral administration of 560 mg/day EMP, 200 mg/day diethylstilbesterol-diphosphate and 30 mg/day hexestrol.
URI: http://hdl.handle.net/2433/122778
Appears in Collections:Vol.26 No.12

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