Thromboelastogramからみた男性老人に対するGestagen剤の長期投与成績 -Chlormadinone acetateについて-

Abstract

Gestagen preparations have been employed in the treatment of prostatic hypertrophy and prostatic cancer. It has become a problem that the oral contraceptive drugs containing gestagen and estrogen at various ratios increase blood coagulating factors and enhance their activities, resulting in genesis of thrombosis and the great role of estrogen played in this problem has been discussed. Considering from the composition of oral contraceptives, however, quantity of gestagen occupies the main part, gestagen also should be examined as to this problem. Effect of chlormadinone acetate medicated for a prolonged period on the function of blood platelets is now being examined and this time the result of thromboelastography on 20 cases administered for 24 months at the longest is reported here. 1) Number of blood platelets and TEG were examined and observation was made by taking the value before administration and the normal value as the standard. 2) Platelet count tended to increase. 3) When the normal values in the course of each case were taken as the standard, no consistent tendency could be observed. 4) When values of premedicated time were taken as the standard, it was considered that TEG showed tendency to be shortened about one minute until 6 months. 5) No apparent tendency was observed in TEG.k and ma. 6) Comparison of 83 times test results with values before administration showed shortening of r, k and increase in ma, however, they were variations within the normal range, showing no tendency of acceleration of coagulation.