泌尿器科領域における尿中Prostaglandin Eの検討

Abstract

Urinary prostaglandin (PG) E levels were measured by radioimmunoassay in 46 males and 24 females with urogenital diseases, in order to evaluate urinary PGE excretion in urogenital diseases and to clarify clinical assessment of urinary PGE measurement in urology. The results obtained were as follows. 1) There were no definite patterns of urinary PGE excretion in 20 patients with urolithiasis, 17 urinary tumors, 8 benign prostatic hyperplasia, and 9 other renal diseases and 6 other genital diseases. Urinary PGE levels in 5 patients with hypertensive diseases and 5 chronic glomerulonephritis or chronic renal failure tended to be low. 2) Urinary PGE levels were 394.5±237.3 ng/day (M±SD) in 46 males and 261.1 ± 117.6 ng/day in 24 females. 3) Urinary PGE levels in 15 patients with more than 150 mmHg of the systolic blood pressure tended to be lower than those in 55 patients with less than 150 mmHg. 4) Urinary PGE levels were significantly lower in 9 patients with less than 50 per cent of total phenolsulfonphthaleinexcretion rate than in 26 patients with more than 80 per cent of that (p<0.05). 5) There were significant correlations between urinary PGE excretion and urine flow (r=0.559, p<0.001, n=70), and urinary sodium excretion (r=0.657, p<0.001, n=69). The present results indicated that urinary PGE excretion showed no definite patterns to the kind of urogenital diseases, but closely related to renal function, urine flow and urinary sodium excretion.