(特集：PIVMECILLINAMによる尿路感染症の治療) 尿中より検出したEnterobacteriaceae4菌種に対するMecillinamの抗菌力に関する検討

Abstract

In vitro antibacterial activity of Mecillinam was studied against clinical isolates of E. coli, K. pneumoniae, E.cloacae and C.freundii in comparison with ST (combination of sulfamethoxazole and trimethoprim) and PPA (pipemidic acid). In case of E. coli and K. pneumoniae, both of which are often isolated from urine, mecillinam showed stronger antibacterial activity than ST and PPA, while, in case of E. cloacae, there was no big difference between 3 compounds and, in case of C.freundii, PPA seems to have stronger activity than mecillinam. As it will be suspected that the resistant strains will increase in future, the change of clinical isolates, trend of the use of antibiotics as well as the antibacterial activity against other bacteria than 4 kinds mentioned above should be constantly checked.