Hemofiltrationの臨床的研究 第3報 : 免疫機能

Abstract

Eight patients of renal insufficiency were treated by hemofiltration (HF) for a period of three months, and the fluctuations of immunity were studied. The following results were obtained: 1) No change was noted in serum immune globulin. 2) Complement protein volume C3c dropped remarkably in the three-month period, while C4 did not change. 3) Peripheral blood lymphocyte count and T cell count notably increased to a normal level after three months of treatment, but the B cell count did not change. 4) The PHA skin test showed significantly increased reaction in three months. As for the PPD skin test, four cases of negative results turned positive at the end of the treating period. Hence, it may be concluded that HF is effective for normalization of cellular immunity, and it is assumed that the excellent removability of middle molecular weight substance of HF has greatly contributed to this result. Meanwhile, it is concluded that HF may be effectively applied to cases of renal insufficiency with marked drop of cellular immunity.