酸性尿酸アンモニウム結石の成因にかんする実験的研究

Abstract

Experimental studies on the formation of ammonium acid urate stones in vitro and in vivo were performed. The results were as follows; 1) In vitro study showed that ammonium acid urate crystals were obtained by inoculating Proteus mirabilis in human urine with high concentration of uric acid. 2) Mixed ammonium acid urate and magnesium ammonium phosphate stones were formed in hyperuricemic rats, induced by oxonate administration, by implanting discs infected by Proteus mirabilis into the bladder. These results disclosed some etiological factors of endemic bladder stone disease in the southeast Asian children.