尿管結石症患者におけるCefsulodinの分腎的尿中濃度

Abstract

In order to confirm that there is difference between urinary excretions of antibiotics by each kidney in urological diseases in which split functions of each kidney differs, cefsulodin concentrations in split urine were measured 40 to 70 minutes following an intravenous bolus injection of 500 mg of cefsulodin in five patients with unilateral ureteral stone. Stone-side urine was sampled from the ureter above the stone and normal-side urine through transurethrally dwelt catheter during the operation. Urine and plasma samples were examined by agar-well plate method using Pseudomonas aeruginosa NCTC 10490 as test organism. The urinary concentrations on the stone-side ranged from 166 to 754.3 µg/ml, whereas the concentrations on the normal-side from 406.3 to 1970µg/ml. Ratios of the stone-side urinary concentration to the normal-side concentration were 0.29 to 0.71. Ratios of the urinary concentration to the plasma concentration of 10.2 to 58.0 on the stone-side, the ratios of 24.3 to 118.7 on the normal side were attained.