男子不妊症の治療経験 第2報 : HCG,HMG各剤の投与量と妊孕性の予後について

Abstract

HCG and HMG were administered for idiopathic male sterilities (noneunuchoidal hypospermatogenesis) to evaluate the change of the sperm counts. 161 cases were divided into four groups (groups 1-4) and between each group no significant differences exsisted in volume of testicle and levels of serum LH, FSH and testosterone. In group 1, which consisted of 17 cases of azoospermia and 16 cases of oligozoospermia (lower than 30×10ml), 5, 000 IU of HCG was administered one time a week, in group 2, which consisted of 33 cases of azoospermia and 50 cases of oligozoospermia, 3, 000 IU of HCG and 75 IU of HMG were administered each one time a week, in group 3, which consisted of 14 cases of azoospermia and 16 cases of oligozoospermia, 3, 000 IU of HCG and 75 IU of HMG were administered one time and three times a week respectively and in group 4, which consisted of 5 cases of azoospermia and 10 cases of oligozoospermia, 75 IU of HMG was administered three times a week. Each regimen was continued from three to fourteen months. For results of therapy, 7 cases (21 %), 34 cases (41 %), 20 cases (66%) and 2 cases (13%) showed increases of sperm counts in each group. In all groups, cases of oligozoospermia had more responses than these of cases of azoospermia.