膀胱腫瘍に対するFilacul Capsule 〔1-(2-tetrahydrofuryl)-5-fluorouracil〕の使用経験

Abstract

Filacul capsule was used to 25 cases of bladder tumor and the therapeutic effects; both antitumor and recurrence-preventive effects were examined. Described below are the results of the study: 1) The therapy was recognized as effective in five of 12 cases (41.7%) for the anti-tumor effects and eleven of 13 cases (84.6%) for recurrence-preventive effects. 2) The anti-tumor effects were recognized for primary tumor cases and found to be correlated with both grade and stage. 3) The recurrence-preventive effects, which were also good against primary tumor cases, were found to be correlated with grade but not with stage. 4) Good correlation was observed between the therapeutic efficacy and the doses. Efficacy was observed in many of the cases dosed more than 100 g. 5) Side effects appeared in 48% of the total cases and the administration was discontinued in 16%. No serious side effects were observed.