Salicylazosulfapyridineによると思われる乏精子症

Abstract

It has been known that some of drugs, such as alkylating agents, have adverse effect on spermatogenesis. Recently, salicylazosulfapyridine (SASP), an effective drug to control ulcerative colitis, has been suspected of reversible toxic effect on semen quality. In 1979, Toth reported six paitents, and Levi and Fisher did four other patients with SASP-treated chronic ulcerative colitis who had poor semen qualities and barren marriage. Rapid improvement in semen quality and pregnancies occurred after discontinuation of SASP, and reintroduction of the drug was followed by rapid deterioration in the semen. Such two patients were recently experienced in our clinic, who had severe oligozoospermia and reduced spermatozoal motility and showed normal baseline levels of LH, FSH and prolactin. We herein reported the cases in association with results of animal study disclosing that SASP did not directly depress spermatogenesis of the testes on histological examination.