Aclacinomycin Aによる膀胱内注入療法の経験

Abstract

In an effort to minimize the local and general side effects and obtain a better result of the treatment with intravesical instillation on the recurrent superficial bladder cancer, we tried this method using aclacinomycin A. The subjects in this experiments were 9 cases with superficial bladder cancer, 30 ml of 300 µg/ml of aclacinomycin. A was instilled into the bladder cavity, 2-3 times every week, total 8-16 times. The results obtained were as follows. Complete disappearance of the tumor was attained in 6 out of the 9 cases and reduction of the tumor size over 50% in 2 out of the 9 cases. No change was observed in the remaining one case. Local side effects such as urinary frequency and pain on urination were found in 3 out of the 9 cases. The general untoward effects were not detected as judged by the examination of peripheral blood, ECG and liver-kidney function. From the results above obtained, it was noted that aclacinomycin A was effective on the recurrent superficial bladder cancer with minimum side effects when instilled intravesicaliy.