CarboquoneとCytosine Arabinosideの併用による膀胱内注入の再発予防効果

Abstract

Prophylactic effects of combined intravesical instillation of cytosine arabinoside and carboquone on recurrence rate of bladder tumor were studied in 42 patients. Thirty ml solution containing cytosine arabinoside 100 mg and carboquone 10 mg was instilled into the bladder once a week for 10 weeks, and once a month for subsequent 10 months. The recurrence rate was 14.6% after 1 year, 27.4% after 2 year, 33.4% after 3 year, 33.4% after 4 and 5 years follow up. On the basis of our observation, it is concluded that the prophylactic instillation therapy with cytosine arabinoside and carboquone is effective for the prevention of postoperative recurrence of bladder tumors.