抗男性ホルモン療法に再燃した前立腫癌進行例に対する多剤併用療法の経験

Abstract

A study was done on 5 patients who had clinically relapsing advanced prostatic carcinoma (stage D) treated with cyclophosphamide, futraful and vincristine. An analysis of the responses was made. 1) Subjective response: Two patients (cases 1, 3) had a partial disappearance of bone pain, and 3 patients (cases 2, 4, 5) had a temporary disappearance then took a turn for the worse in a month and thereafter remained apparently stable. The duration of the subjective responses varied from 3 to 5 months. 2) Objective response: Partial regression - A partial objective remission was seen in 1 (case 1) of the 5 patients. Elevated acid and alkaline phosphatase returned to normal, bone metastasis remained stable and uptake of the bone scintigram decreased, edema of the lower extremities was reduced. Stable - Four patients remained stable. Elevated acid and/or alkaline phosphatase decreased, though did not return to normal (cases 2, 5) or stable (cases 3, 4). None of the patients showed progression. 3) Toxicity: Various degrees of nausea, vomiting, anorexia, hepatotoxicity were present in all patients. Three patients had leukopenia, and one patient had pancytopenia. Significant renal toxicity was observed in one patient (case 2). 4) Outcome: All 5 patients died I to 16 months from the start of chemotherapy.