泌尿器科領域におけるNeocarzinostatinに関する臨床的研究 第1報 : 膀胱内投与による所属リンパ節移行について

Abstract

Two million I.U. of neocarzinostatin (NCS) was administered to 8 patients with bladder tumor by intravesical instillation before operations. The concentration of each tissue (normal bladder, bladder tumor and lymph nodes) and serum concentration were measured. The following results were obtained. 1) NCS is absorbed into the normal bladder and bladder tumor by intravesical instillation. 2) Absorption into regional lymph nodes was partly noted. 3) It is about two hours after intravesical instillation that NCS migrates towards the serum. These results suggest that chemotherapy for regional metastatic lymph nodes after TUR-Bt would be possible by intravesical instillation of NCS.