インポテンス患者における八味地黄丸の効果

Abstract

We studied the data obtained by administering Tsumura Hachimijiogan to 28 impotent patients and 29 normal individuals. During two weeks of administration, we assessed the efficacy of the drug by examining the answers of the subjects to a questionnaire handed out before administration, the Cornell Medical Index (C.M.I.) and the results of the Yatabe-Guilford (Y-G) tests. We also measured blood testosterone, 17-KS and 17-OHCS, before and after administration to assess the influence of Hachimijiogan on hormone production. 1) Ability of erection: An increased ability of erection was observed in 65.4% of the impotent patients and an amelioration of morning erection in 50% of the patients. An increased ability of erection was observed in 36% of the control subjects, and an amelioration of morning erection in 24%. 2) Efficacy rate of Hachimijogan was 64% in the control group and 76.9% in the impotent group. The efficacy rate as observed by age was 100% for the control subjects who were over 40 years old; it was smallest for the control subjects in their thirties. However, little difference in the efficacy rate was observed with age in the impotent group. 3) Efficacy rate for problem groups: There was no difference between the efficacy rate for the problem groups in the C.M.I. and Y-G tests and the overall efficacy. 4) Efficacy rate by habitus: The drug was very effective for 71.4% of the impotent patients who had a slender build. 5) The side effects most frequently observed were gastroenteritic disorders. In three cases, drug administration was discontinued because of side effects. Side effects were observed at the highest percentage in pyknic subjects, appearing in more than half of them. 6) Blood testosterone, urinary 17-KS, 17-OHCS: There was no significant difference between the values obtained for the patients or control subjects before and after the administration of Hachimijiogan.