腎細胞癌の多発肺転移例に対する気管支動脈内制癌剤注入療法の効果

Abstract

We treated 9 patients who had pulmonary metastases from renal cell carcinoma with bronchial arterial infusion therapy (BAI). Of 9 cases, BAI was performed 32 times using Seldinger's angiographic technique. The anti-cancel' drugs were infused through an angiographic catheter into the bronchial artery by a one shot infusion lasting from 10 to 20 minutes. The drugs used for BAI were MMC, Carbazilquinone (CQ), ACNU and adriamycin (ADM). The dosage of the drugs was MMC 10-20 mg, CQ 3-6 mg, ACNU 100 mg, ADM 20-40 mg. Bronchial arteriography revealed irregular hypervascularity and tumor stain in most of the cases. An effective response (reduction rate>20%) was observed in 4 patients (33.3%) metastatic foci had disappeared completely in one of these 4 cases. The other 5 patients had no change or had progression of disease. No serious complication was observed. This method appears to have therapeutic value in the treatment of patients with multiple lung metastases.