腎癌の肺転移の改善,消失した2例

Abstract

Usually treatment of pulmonary metastasis from renal cell carcinoma is done by nephrectomy and hormone therapy and/or chemotherapy. (Case 1) A 51-year old man was hospitalized because of right flank mass and pain. He was diagnosed to have renal cell carcinoma by IVP and RP and angiography. Nephrectomy and lymph node dissection were done. After operation he was given OK-4321.0KE and medroxyprogesterone acetate 100 mg every day. Then he was discharged from hospital. Six months after discharge, he was re-hospitalized because of cough and sputum. Pulmonary metastasis from renal cell carcinoma was suspected from chest X-P, and the patient was given CDDP 25 mg. Nine days after medication, regression of pulmonary metastasis was seen in the chest X-Po Since then he has been given medroxyprosesterone acetate 200 mg every day. (Case 2) A 71-year old man was hospitalized because of macroscopic hematuria and right lower abdominal pain. He was diagnosed to have renal cell carcinoma by IVP and RP and angiography. Nephrectomy was done. Postoperative medication of vinblastine 7 mg and medroxyprogesterone acetate 100 mg was given every day. Then he was discharged from hospital. About four years after discharge, a coin lesion was seen at the right pulmonary hilus. He was given radiotherapy ([60]Co 180 rad/day=total 4000 rad), and medroxyprogesterone acetate 100 mg/day and 5-FU 100 mg every day for several days after the radiotherapy. The coin lesion at the pulmonary hilus vanished from the che3t X-Po He has been given medroxyprogesterone acetate 100 mg and 5-FU 100 mg every day since. Recurrence of pulmonary metastasis has not been seen.