泌尿器科的腎疾患および腎移植後における尿中N-Acetyl-β-D-Glucosaminidase活性値

Abstract

Activity of urinary N-acetyl-β-D-glucosaminidase (u-NAG) has been studied in patients with urological renal diseases and in renal allograft recipients. Elevation of u-NAG was more marked after nephrolithotomy compared to the elevation after pyeloplasty or pyelolithotomy. Increased u-NAG level was highest on about the 7th postoperative day and decreased gradually to within the normal range. The elevation of u-NAG correlated to the degree of renal damage. Hydronephrosis after ureteroneovesicostomy was accompanied by an elevated u-NAG level which was normalized after remission of hydronephrosis. In renal transplant recipients the elevation of u-NAG preceeded the clinical diagnosis of acute rejection, and was thought to be of diagnostic value. Urinary NAG assay is simple and considered to be a useful aid in the follow-up examination after urologic renal surgery as an indicator of renal damage.