限局性膀胱アミロイドーシスの1例

Abstract

A 25-year-old man was hospitalized with the complaints of gross hematuria and pain on urination. Cystoscopic examination revealed dark-red, nodular-surfaced tumors and dark-red edematous swelling with hemorrhage in the left lateral and basal epitherium of the bladder. Excretory urogram showed normal upper urinary tract. CT scan did not realize the infiltration to the bladder wall. Preoperative diagnosis was non-papillary bladder cancer. Partial cystectomy was performed on April 21, 1981. Histological examination revealed amyloid deposited in the submucosa, vessel walls and inner muscular layer. Amyloid deposits were positively stained with Congo-red and amyloid fibrils were observed by electron microscopy. Serum electrophoresis was normal and urinary Bence-Jones protein was negative. Amyloid deposits were not found by rectal and skin biopsy. From these findings, localized amyloidosis of the bladder was confirmed. Our case is the eleventh in the Japanese literature. No recurrence was detected for 7 months after operation.