膀胱癌患者の細胞性免疫能に関する研究 第8報 : 患者末梢血リンパ球のADCC活性について

Abstract

Host resistance against malignant neoplasms is not clear in human tumor bearers. Many immunological parameters are measured in patients with carcinoma, but these are usually not specific to the carcinoma. As a preliminary experiment for tumor specific assay, ADCC (antibody dependent cell-mediated cytotoxicity) activity and NPFC (natural plaque forming cell) population were measured by means of plaque formation of sheep red cells on a microplate. Twenty-six patients with urinary bladder carcinoma and 20 control subjects were examined. Both ADCC activity and NPFC population were significantly depressed in patients group compared with control subjects. Especially, the ADCC activity was very low in the high grade group of patients whereas NPFC was lowest in the high stage group, but there was no difference between these two groups concerning total host response (ADCC+NPFC). We discuss about host resistance in patients with advanced urinary bladder carcinoma.