単純性腎嚢胞液中へのamikacinの移行について --特にsubstrate-labeled fluorescent immunoassay法による検討--

Abstract

Acute infection in simple renal cysts is said to be considerably resistant to all forms of chemotherapy. Following the intramuscular injection of amikacin, the levels of amikacin in the cyst fluid, serum and urine of 11 patients with simple renal cysts were quantitatively determined using the substrate-labeled fluorescent immunoassay kit and microbiological assay system. The cyst fluid samples were obtained by means of percutaneous puncture or surgical approach. A biochemical analysis of the fluid samples revealed that the electrolyte composition and protein concentration of the fluid are similar to those of the interstitial fluid. Despite there being an adequate concentration in the urine and serum, there was no evidence of amikacin in the fluid samples. These data may explain why the infection in the cysts is highly resistant to chemotherapy.