褐色細胞腫10例の臨床的観察

Abstract

Ten cases of pheochromocytoma seen at our hospitals between 1960 and 1981 are presented. The ages of the patients differed greatly. Seven patients were females and 3 were males. Six patients had a right adrenal tumor, 3 patients had a left adrenal tumor, and one patient had an extra-adrenal tumor. In the clinical findings, hypertension was recognized in 9 cases, palpitation in 7 cases, headache in 6 cases, nausea and vomiting in 5 cases, headache in 6 cases, nausea and vomiting in 5 cases and sweatening in 2 cases. A diagnosis of renal cancer was made for the case without hypertension, which was found to be pheochromocytoma at autopsy. The urinary catecholamine levels in 24 hour collections were high in 8 cases excluding the paroxysmal-type case. The urinary level of adrenaline of the extra-adrenal case was higher than that of noradrenaline. For locating tumors, computed tomography, retroperitoneal pneumography, ultrasonography, aortography and so on were performed, the first two methods of which showed a diagnostic accuracy of 100%. Computed tomography which was not invasive was found the most helpful method. Blood transfusion and administration of phenoxybenzamine and propranolol were performed as preoperative management on 5 patients, but none of them developed hypotension after tumor extirpation. The blood pressure of9 patients who underwent operation became normal after operation.