片腎障害時におけるGentamicinの腎毒性に関する実験的研究

Abstract

To clarify the effect on each kidney of the administration of a nephrotoxic antibiotic when there is unilateral renal dysfunction, 20 mg/kg/day of gentamicin (GM) was continuously administered to rabbits who each had complete ligation of one ureter. The results were as follows: The 131I-hippuran uptake of the renal cortical slices used as an indicator of renal dysfunction well reflected the degree of the dysfunction of the renal tubules. It may be used as an indicator of the renal dysfunction of a degree lower than that causing increase of serum creatinine and BUN. When 20 mg/kg/day of GM was continuously administered to the rabbits with unilateral renal dysfunction, the condition of the dysfunctioned kidney was aggravated by GM up to the 4th day; after the 7th day the contralateral kidney (intact kidney) was affected by the drug. When 20 mg/kg/ day of GM was continuously administered for two weeks to the rabbits with unilateral renal dysfunction and then discontinued, the slightly increased serum creatinine and BUN were almost normalized after one week. However, the hippuran uptake of the contralateral kidney and the histolcgical findings disclosed an effect of GM even after 4 weeks. When WIT is given to the dysfunctioned kidney, the damage it causes, which is reversible in the normal kidney, may become irreversible. Therefore, it is necessary to study and determine the WIT tolerated depending on the degree of kidney damage.