尿路性器悪性腫瘍に対するcis-Diamminedichloroplatinumの使用経験

Abstract

Cisplatin was administered to eleven patients bearing urogenital malignancies to evaluate clinical efficacy. (1) In testicular tumor cases combination therapy with cisplatin, bleomycin and vinblastine was very effective resulting in 100% efficacy rate. Effect of this combination regimen was noticed in every tumor of germ cell origin and malignant interstitial cell tumor suggesting wide anti-tumor spectrum of this regimen. (2) Efficacy of cisplatin against prostatic cancer was noticed only in 25% of cases by single administration of this drug. Therefore, combination with anti-androgen therapy or other anti-cancer chemotherapeutics should be considered. (3) Efficacy of single administration of cisplatin was noticed in no case ofuroepithelial tumors. Therefore, radiation therapy and other anti-cancer drugs should be combined to obtain anti-tumor effect against malignancies of uroepithelial origin. (4) Renal toxicity and ototoxicity could be avoided by confluent fluid administration combined with diuretics. Therefore, this drug seemed relatively safe to be administered to any case in this respect. However, administration of this drug to aged patients was hindered by rather severe gastrointestinal symptoms.