前立腺癌に対するallylestrenolと5-fluorouracilの併用投与の有効性に関するphase 2 study

Abstract

Fifty five patients with prostatic carcinoma were treated with hexestrol (HEX), allylestrenol (AEN), and 5-fluorouracil (5-FU). Patients were given HEX (30-60 mg/day) or AEN (50 mg/day) with or without a combination of 5-FU (200 mg/day). The effectiveness of drugs was evaluated by the response rate at the interval of 3, 6, 12 and 24 months. The response rate of HEX declined linearly to 48% at 24 months. That of AEN was judged to be about the same as HEX. 5-FU enhanced the effect of HEX or AEN and elevated their response rate up to 70% at 24 months. Concurrent administration of AEN and 5-FU did not accompany with any severe side effects except slight gastric disturbance and retained sexual potence.