原発性前立腺移行上皮癌の1例

Abstract

A case of primary transitional cell carcinoma of the prostate was reported. The patient was a 64-year-old man who had complained of the pain in the right lower abdomen and the right leg. Initially it was confirmed that the patient had a metastatic adenocarcinoma of the ischial bone by its biopsy in the other clinic and he was sent to our hospital. The histological diagnosis was mixed type of transitional cell carcinoma with adenocarcinoma by needle biopsy and transurethral resection of the prostate. Nonneoplastic change of the bladder epithelium was found by random transurethral cold punch biopsy of the urinary bladder. Initially, the treatment consisted of orchiectomy and intravenous administration of diethylstilbestrol diphosphate. Oral administration of N1-(2-tetrahydrofuryl)-5-f1uorouracil and intramuscular injection of picibanil were added after the confirmation of histological diagnosis. About 2 months later, this treatment proved to be non-effective histologically despite of decrease in serum acid phosphatase and prostatic acid phosphatase. Accordingly doxorubicin hydrochloride was administered for the next treatment. Doxorubicin hydrochloride was effective on the primary lesion, but did not effect on the osseous metastatic lesions. Then finally he was treated with cis-diamminedichloroplatinum. The complete disappearance of primary and osseous metastatic lesions were shown by roentgenography and bone scanning. Cis-diamminedichloroplatinum appears to be the most effective drug for the treatment of advanced transitional cell carcinoma of the prostate.